Allele/Variant

Runx1tm2.1(cre/Esr1*)Ims

Species
Mus musculus
Symbol
Runx1tm2.1(cre/Esr1*)Ims
Category
allele
Allele of gene
Runx1
Transgenic Constructs
Synonyms
  • Runx1SACRE
Description
A targeting vector was composed of the sequence for a tamoxifen-inducible cre recombinase (flanked by two mutated estrogen receptors, MerCreMer) with the Engrailed-2 splice acceptor (En2SA) sequence preceding the coding region and a transcription STOP sequence followed the cre/Esr1*. A floxed neo selection cassette followed the STOP. Insertion of the En2SA sequence prevents splicing of the STOP out and disrupted Runx1 expression from both the proximal P2 and distal P1 promoters. The neo was subsequently deleted from the allele.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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