Allele/Variant

Mterf1atm1.2Lrsn

Species
Mus musculus
Symbol
Mterf1atm1.2Lrsn
Category
allele
Allele of gene
Mterf1a
Transgenic Constructs
None
Synonyms
None
Description
The second exon of Mterf1a was flanked by a loxP site and an FRT-flanked neomycin resistance cassette with a loxP site. The second exon of Mterf1b was replaced with a hygromycin resistance cassette. ES cells were selected for both mutations on the same chromosome. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the second exon of Mterf1a. Western blot analysis confirmed the absence of protein expression in the liver.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations