Allele/Variant

Tg(Prnp-ATXN3*148Q)NES.24Olri

Species
Mus musculus
Symbol
Tg(Prnp-ATXN3*148Q)NES.24Olri
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
The mouse prion promoter (containing 1140 bp of the prion protein gene upstream of exon 1, the complete exon 1, intron 1, and the first 52 bp of exon 2) drives the expression of the full-length human ATAXIN-3 (ATAXIN-3c isoform) containing 148 CAG repeats. To transport ATAXIN-3 into the cytoplasm, the nuclear export signal (NES) of the heat-stable inhibitor of the cAMP-dependent protein kinase was attached to ATAXIN-3. Five lines were created: NES.17, NES.24, NES.34, NES.40 and NES.42.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations