Allele/Variant

Trp63tm2.2Elrf

Species
Mus musculus
Symbol
Trp63tm2.2Elrf
Category
allele
Allele of gene
Trp63
Transgenic Constructs
None
Synonyms
  • deltaNp63delta
Description
A loxP site was inserted upstream of exon 3' and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted downstream of exon 3'. The neo cassette was removed through subsequent flp-mediated recombination. The floxed exon 3' was deleted through cre-mediated recombination. This deletion specifically knocks out the specific deltaN isoform that uses an alternative exon 3 that lacks the acidic transactivation domain sequence.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations