Allele/Variant

Fpr3del

Species
Mus musculus
Symbol
Fpr3del
Category
allele
Allele of gene
Fpr3
Transgenic Constructs
None
Synonyms
  • Fpr3delta424-435
Description
Nineteen strains (129X1/Sv, 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, AKR/J, A/J, BALB/cJ, C3H/HeH, C3H/HeJ, CBA/J, DBA/1J, DBA/2J, LP/J, NZO/HILtJ, RF/J, SEA/GnJ, FVB/NCrl, FVB/NJ, BUB/BnJ, ZALENDE/EiJ, LEWES/EiJ and WSB/EiJ) contain an in-frame 12 bp deletion within the gene spanning the basepairs 424 to 435. Immunocytochemistry analysis confirmed the absence of protein expression in vomeronasal sensory epithelium and neutrophil granulocytes. Furthermore, HEK293T cells expressing Fpr3del showed missing receptor protein expression and loss of function. This deletion is not detected in 13 other strains (C57Bl/6NCrl, C57Bl/6NJ, C57Bl/10J, C57BR/cdJ, C57L/J, C58/J, I/LnJ, NZB/B1NJ, NZB/Ola, NZW/LacJ, KK/HiJa, NOD/ShiLtJ, ST/bJ, SPRET/EiJ, CZE/DT, PWK/PhJ, GER/DT, FRA/DT, CAST/EiJ and KAZ/DT).
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations