Allele/Variant

Sdc2tm1c(KOMP)Wtsi

Species
Mus musculus
Symbol
Sdc2tm1c(KOMP)Wtsi
Category
allele
Allele of gene
Sdc2
Transgenic Constructs
None
Synonyms
  • Sdc2flox
Description
The L1L2_Bact_P cassette was inserted at position 33023250 of Chromosome 15 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 33024207. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations