Allele/Variant

Wapltm1.1Kpfe

Species
Mus musculus
Symbol
Wapltm1.1Kpfe
Category
allele
Allele of gene
Wapl
Transgenic Constructs
None
Synonyms
  • WaplFlox
Description
The targeting vector is designed to insert a loxP site upstream of the endogenous promoter (- 517 bp relative to major transcriptional start site), and a loxP site downstream of exon 2 (+3641 relative to the major transcriptional start site). An FRT-flanked neomycin cassette is also part of the construct. Flp-mediated recombination removed the neo cassette. This allele is a hypomorph, although RNA levels are not altered, WAPL protein levels are reduced by 2 fold.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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