Predicted to enable DNA replication origin binding activity. Involved in DNA amplification and DNA replication initiation. Located in nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including embryonic/larval midgut primordium; eye disc posterior to the morphogenetic furrow; ganglia; nurse cell; and ventral furrow. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1).
FB Description
Origin recognition complex subunit 1 (Orc1) encodes the largest subunit of the origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells. The ATPase activity of the product of Orc1 is critical for the formation and function of the pre-replicative complex. The regulated degradation of the product of Orc1 by ubiquitin-mediated proteolysis after initiation of DNA replication helps to prevent re-replication.