Gene

Orc1

Species
Drosophila melanogaster
Symbol
Orc1
Name
Origin recognition complex subunit 1
Synonyms
  • CG10667
  • DmORC1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA replication origin binding activity. Involved in DNA amplification and DNA replication initiation. Located in nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including embryonic/larval midgut primordium; eye disc posterior to the morphogenetic furrow; ganglia; nurse cell; and ventral furrow. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1).
FB Description
Origin recognition complex subunit 1 (Orc1) encodes the largest subunit of the origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells. The ATPase activity of the product of Orc1 is critical for the formation and function of the pre-replicative complex. The regulated degradation of the product of Orc1 by ubiquitin-mediated proteolysis after initiation of DNA replication helps to prevent re-replication.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10763
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Alleles and Variants

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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7.5225M7.5230M7.5235M7.5240M7.5245M7.5250M7.5255M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions