Gene

GluClα

Species
Drosophila melanogaster
Symbol
GluClα
Name
Glutamate-gated chloride channel subunit alpha
Synonyms
  • BcDNA:HL07853
  • CG6300
Biotype
protein coding gene
Automated Description
Enables extracellularly glutamate-gated chloride channel activity. Involved in chloride transport. Predicted to be located in membrane. Is expressed in adult head; larval central nervous system; optic lobe narrow field columnar neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Orthologous to several human genes including GLRA1 (glycine receptor alpha 1) and GLRA2 (glycine receptor alpha 2).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18945
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            19.735M19.740M19.745M19.750M19.755M19.760M19.765M19.770M19.775M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            GluClα molecule type
            Interactor gene
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              Genetic Interactions

              GluClα role
              GluClα genetic perturbation
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