Gene

scf

Species
Drosophila melanogaster
Symbol
scf
Name
supercoiling factor
Synonyms
  • anon-EST:Posey14
  • BEST:CK02682
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity. Involved in DNA topological change; dosage compensation by hyperactivation of X chromosome; and positive regulation of DNA-templated transcription. Located in cytoplasm; nucleus; and polytene chromosome puff. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval hemocyte; nephrocyte; and somatic trunk mesoderm derivative. Orthologous to several human genes including CALU (calumenin).
FB Description
supercoiling factor (scf) encodes two polypeptides: DCB45 and its N-teminally truncated form Scf. Scf is a nuclear protein that introduces negative supercoils into DNA in conjunction with topoisomerase II. DCB45 is an endoplasmic reticulum-resident protein.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10827
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
1.2988M1.2990M1.2992M1.2994M1.2996M1.2998M1.3000M1.3002M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions