Predicted to enable calcium ion binding activity. Involved in DNA topological change; dosage compensation by hyperactivation of X chromosome; and positive regulation of DNA-templated transcription. Located in cytoplasm; nucleus; and polytene chromosome puff. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval hemocyte; nephrocyte; and somatic trunk mesoderm derivative. Orthologous to several human genes including CALU (calumenin).
FB Description
supercoiling factor (scf) encodes two polypeptides: DCB45 and its N-teminally truncated form Scf. Scf is a nuclear protein that introduces negative supercoils into DNA in conjunction with topoisomerase II. DCB45 is an endoplasmic reticulum-resident protein.