Enables several functions, including nuclear receptor binding activity; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; and transcription corepressor activity. Involved in lysine catabolic process; negative regulation of ecdysone receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in adult head; adult heart; and salivary gland. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase).
FB Description
Lysine ketoglutarate reductase/saccharopine dehydrogenase (LKRSDH) encodes a bifunctional enzyme that catalyzes the first two steps in the lysine degradation pathway. Independently of its enzymatic activity, it also acts as a transcriptional corepressor in ecdysone signaling.