Gene

LKRSDH

Species
Drosophila melanogaster
Symbol
LKRSDH
Name
Lysine ketoglutarate reductase/saccharopine dehydrogenase
Synonyms
  • anon-WO0149856.1
  • BEST:CK02318
Biotype
protein coding gene
Automated Description
Enables several functions, including nuclear receptor binding activity; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; and transcription corepressor activity. Involved in lysine catabolic process; negative regulation of ecdysone receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in adult head; adult heart; and salivary gland. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase).
FB Description
Lysine ketoglutarate reductase/saccharopine dehydrogenase (LKRSDH) encodes a bifunctional enzyme that catalyzes the first two steps in the lysine degradation pathway. Independently of its enzymatic activity, it also acts as a transcriptional corepressor in ecdysone signaling.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11133
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Alleles and Variants

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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7.7915M7.7920M7.7925M7.7930M7.7935M7.7940M7.7945M7.7950M7.7955M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions