Gene

goe

Species
Drosophila melanogaster
Symbol
goe
Name
gone early
Synonyms
  • BcDNA:LD21405
  • CG9634
Biotype
protein coding gene
Automated Description
Involved in negative regulation of stem cell differentiation and oogenesis. Located in plasma membrane. Is expressed in several structures, including adult head; mesectoderm; mesectoderm anlage; midline primordium; and unpaired neurons. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1).
FB Description
gone early (goe) encodes a non-peptidase homolog of Neprilysin (M13) family metalloendopeptidases. It is expressed in various EGF (epidermal growth factor) ligand-producing cells and can attenuate EGFR signaling. The roles of the procut of goe include regulation of primordial germ cell differentiation and germline stem cell formation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11733
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
16.728M16.730M16.732M16.734M16.736M16.738M16.740M16.742M16.744M16.746M16.748M16.750M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions