Involved in negative regulation of stem cell differentiation and oogenesis. Located in plasma membrane. Is expressed in several structures, including adult head; mesectoderm; mesectoderm anlage; midline primordium; and unpaired neurons. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1).
FB Description
gone early (goe) encodes a non-peptidase homolog of Neprilysin (M13) family metalloendopeptidases. It is expressed in various EGF (epidermal growth factor) ligand-producing cells and can attenuate EGFR signaling. The roles of the procut of goe include regulation of primordial germ cell differentiation and germline stem cell formation.