Gene

Pits

Species
Drosophila melanogaster
Symbol
Pits
Name
Protein interacting with Ttk69 and Sin3A
Synonyms
  • BcDNA:RE48052
  • BEST:RE18684
Biotype
protein coding gene
Automated Description
Enables ubiquitin protein ligase activity. Involved in regulation of gene expression. Located in cytoplasm and nuclear periphery. Colocalizes with polytene chromosome. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; presumptive embryonic/larval central nervous system; and synaptic neuropil domain. Used to study central nervous system disease and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14 and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Orthologous to several human genes including IRF2BP1 (interferon regulatory factor 2 binding protein 1) and IRF2BPL (interferon regulatory factor 2 binding protein like).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10816
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
12.570M12.572M12.574M12.576M12.578M12.580M12.582M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions