Gene

Hrs

Species
Drosophila melanogaster
Symbol
Hrs
Name
Hepatocyte growth factor regulated tyrosine kinase substrate
Synonyms
  • CG2903
  • dHrs
Biotype
protein coding gene
Automated Description
Enables ubiquitin binding activity. Involved in several processes, including endosomal transport; regulation of epithelial cell migration; and regulation of signal transduction. Located in endosome. Is expressed in adult head; embryonic/larval hemocyte; and organism. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).
FB Description
Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs) encodes a protein that, together with the product encoded by Stam, forms the ESCRT-0 complex. This complex is responsible for the initial selection of ubiquitinated proteins that are ultimately degraded in lysosomes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46275
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
2.7400M2.7405M2.7410M2.7415M2.7420M2.7425M2.7430M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions