Enables ubiquitin binding activity. Involved in several processes, including endosomal transport; regulation of epithelial cell migration; and regulation of signal transduction. Located in endosome. Is expressed in adult head; embryonic/larval hemocyte; and organism. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).
FB Description
Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs) encodes a protein that, together with the product encoded by Stam, forms the ESCRT-0 complex. This complex is responsible for the initial selection of ubiquitinated proteins that are ultimately degraded in lysosomes.