Gene

Smn

Species
Drosophila melanogaster
Symbol
Smn
Name
survival motor neuron
Synonyms
  • CG16725
  • DmSMN
Biotype
protein coding gene
Automated Description
Enables alpha-actinin binding activity. Involved in several processes, including chemical synaptic transmission; protein-RNA complex assembly; and synapse organization. Located in Z disc; neuromuscular junction; and nuclear body. Part of several cellular components, including SMN complex; SMN-Gemin2 complex; and SmD-containing SMN-Sm protein complex. Is expressed in several structures, including adult head; anterior endoderm anlage; ganglia; germline cell; and gonad. Used to study childhood spinal muscular atrophy; intermediate spinal muscular atrophy; juvenile spinal muscular atrophy; and spinal muscular atrophy. Human ortholog(s) of this gene implicated in Werdnig-Hoffmann disease; adult spinal muscular atrophy; intermediate spinal muscular atrophy; juvenile spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human SMN1 (survival of motor neuron 1, telomeric) and SMN2 (survival of motor neuron 2, centromeric).
FB Description
survival motor neuron (Smn) encodes the eponymous member of the SMN complex, which functions as an assembly chaperone for Sm-class small nuclear ribonucleoproteins. The SMN complex contains three other 'Gemin' proteins encoded by Gem2, Gem3 and rig. Smn is essential for viability but higher levels of the protein are required for proper neuromuscular development and function.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR39267
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
16.5804M16.5806M16.5808M16.5810M16.5812M16.5814M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions