Predicted to enable 3'-5' DNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of U5 snRNP. Predicted to be active in nucleus. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3).
FB Description
obelus (obe) encodes a Ski2-family helicase that regulates alternative mRNA splicing of crb. It is required for cell polarity and adherens junction organization.