Gene

Nep4

Species
Drosophila melanogaster
Symbol
Nep4
Name
Neprilysin 4
Synonyms
  • CG4058
  • DmeNEP4
Biotype
protein coding gene
Automated Description
Enables endopeptidase activity. Involved in proteolysis. Located in extracellular space and sarcoplasmic reticulum. Is expressed in several structures, including brain; glial cell; male germline cell; pericardial cell; and somatic muscle cell. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2T; X-linked dominant hypophosphatemic rickets; cerebral amyloid angiopathy; membranous glomerulonephritis; and neurodegenerative disease (multiple). Orthologous to several human genes including MME (membrane metalloendopeptidase) and MMEL1 (membrane metalloendopeptidase like 1).
FB Description
Neprilysin 4 (Nep4) encodes a metallopeptidase considered to cleave and thus inactivate signaling peptides in the extracellular space. It contributes to muscle integrity and male fertility.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11733
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
20.653M20.654M20.655M20.656M20.657M20.658M20.659M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions