Predicted to enable G protein-coupled receptor binding activity. Involved in several processes, including locomotory exploration behavior; negative regulation of signal transduction; and positive regulation of protein desumoylation. Located in cytosol. Is expressed in several structures, including adult head; cuticular specialization; epithelium; female germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in glioblastoma; myopia; nicotine dependence; opiate dependence (multiple); and retinal disease (multiple). Orthologous to several human genes including ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2).
FB Description
kurtz (krz) encodes a beta-arrestin (non-visual arrestin) involved in the desensitization and endocytic internalization of G protein coupled receptors, thus downregulating their activity. It also controls other signaling pathways, including Notch, receptor tyrosine kinase, Hedgehog, and Toll. It is required maternally for normal embryonic patterning and zygotically for larval viability.