Gene

krz

Species
Drosophila melanogaster
Symbol
krz
Name
kurtz
Synonyms
  • 0952/14
  • Arr2
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor binding activity. Involved in several processes, including locomotory exploration behavior; negative regulation of signal transduction; and positive regulation of protein desumoylation. Located in cytosol. Is expressed in several structures, including adult head; cuticular specialization; epithelium; female germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in glioblastoma; myopia; nicotine dependence; opiate dependence (multiple); and retinal disease (multiple). Orthologous to several human genes including ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2).
FB Description
kurtz (krz) encodes a beta-arrestin (non-visual arrestin) involved in the desensitization and endocytic internalization of G protein coupled receptors, thus downregulating their activity. It also controls other signaling pathways, including Notch, receptor tyrosine kinase, Hedgehog, and Toll. It is required maternally for normal embryonic patterning and zygotically for larval viability.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11792
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
32.046M32.047M32.048M32.049M32.050M32.051M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions