Gene

LpR2

Species
Drosophila melanogaster
Symbol
LpR2
Name
Lipophorin receptor 2
Synonyms
  • a2M-receptor-like
  • CG31092
Biotype
protein coding gene
Automated Description
Enables lipoprotein particle binding activity. Involved in several processes, including mushroom body development; receptor-mediated endocytosis; and transport across blood-brain barrier. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic central brain neurons; female germline cell; ganglia; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor).
FB Description
Lipophorin receptor 2 (LpR2) encodes a transmembrane receptor. A subset of LpR2-encoded isoforms are involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24270
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            25.700M25.705M25.710M25.715M25.720M25.725M25.730M25.735M25.740M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            LpR2 molecule type
            Interactor gene
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              Genetic Interactions

              LpR2 role
              LpR2 genetic perturbation
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