Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; positive regulation of iron ion transmembrane transport; and positive regulation of viral entry into host cell. Located in fusome and rough endoplasmic reticulum. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; epidermis; female germline cell; and gut section. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2).
FB Description
Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel.