Gene

Sec61α

Species
Drosophila melanogaster
Symbol
Sec61α
Name
Sec61 alpha subunit
Synonyms
  • 0455
  • anon-WO0118547.195
Biotype
protein coding gene
Automated Description
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; positive regulation of iron ion transmembrane transport; and positive regulation of viral entry into host cell. Located in fusome and rough endoplasmic reticulum. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; epidermis; female germline cell; and gut section. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2).
FB Description
Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10906
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
6.4775M6.4780M6.4785M6.4790M6.4795M6.4800M6.4805M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions