Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in fusome. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; female germline cell; follicle cell; ganglia; and somatic muscle cell. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c).
FB Description
Vacuolar H[+] ATPase 16kD subunit 1 (Vha16-1) encodes the proteolipid component of V-ATPase, which is a multi-functional channel protein. It contributes to vesicle-membrane fusion, hydrophilic molecule transport and intercellular communication.