Gene

dop

Species
Drosophila melanogaster
Symbol
dop
Name
drop out
Synonyms
  • CG6498
  • MAST 205
Biotype
protein coding gene
Automated Description
Enables protein kinase activity. Involved in several processes, including border follicle cell migration; dosage compensation by hyperactivation of X chromosome; and lipid droplet transport along microtubule. Located in cytoplasm. Is expressed in adult head; anterior midgut primordium; organism; posterior midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108; female breast cancer; and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to several human genes including MAST1 (microtubule associated serine/threonine kinase 1); MAST2 (microtubule associated serine/threonine kinase 2); and MAST3 (microtubule associated serine/threonine kinase 3).
FB Description
drop out (dop) encodes a microtubule-associated Ser/Thr (MAST) protein kinase. Among its potential substrates is the microtubule motor Dynein. The product of dop is required for membrane growth and polarity during cell formation in the early cleavage stage embryo.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
15.567M15.568M15.569M15.570M15.571M15.572M15.573M15.574M15.575M15.576M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions