Enables protein kinase activity. Involved in several processes, including border follicle cell migration; dosage compensation by hyperactivation of X chromosome; and lipid droplet transport along microtubule. Located in cytoplasm. Is expressed in adult head; anterior midgut primordium; organism; posterior midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108; female breast cancer; and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to several human genes including MAST1 (microtubule associated serine/threonine kinase 1); MAST2 (microtubule associated serine/threonine kinase 2); and MAST3 (microtubule associated serine/threonine kinase 3).
FB Description
drop out (dop) encodes a microtubule-associated Ser/Thr (MAST) protein kinase. Among its potential substrates is the microtubule motor Dynein. The product of dop is required for membrane growth and polarity during cell formation in the early cleavage stage embryo.