Gene

ROCK1

Species
Homo sapiens
Symbol
ROCK1
Name
Rho associated coiled-coil containing protein kinase 1
Synonyms
  • MGC131603
  • MGC43611
Biotype
protein coding gene
Automated Description
Enables Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of metabolic process; regulation of cytoskeleton organization; and regulation of epithelial cell differentiation. Predicted to be located in lamellipodium; plasma membrane; and ruffle. Predicted to be active in Schaffer collateral - CA1 synapse; cytoplasmic stress granule; and cytoskeleton.
RGD Description
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22988
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            20.96M20.98M21.00M21.02M21.04M21.06M21.08M21.10M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ROCK1 molecule type
            Interactor gene
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              Genetic Interactions

              ROCK1 role
              ROCK1 genetic perturbation
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