TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF2J
Biotype
protein coding gene
Automated Description
Enables DNA binding activity; DNA-binding transcription factor binding activity; and transcription coactivator activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Part of SAGA complex; transcription factor TFIID complex; and transcription factor TFTC complex.
RGD Description
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]