Enables peptide antigen binding activity; protein kinase binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of myotube differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MAML1-RBP-Jkappa- ICN1 complex.
RGD Description
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]