Gene

MAML1

Species
Homo sapiens
Symbol
MAML1
Name
mastermind like transcriptional coactivator 1
Synonyms
  • FLJ53540
  • KIAA0200
Biotype
protein coding gene
Automated Description
Enables peptide antigen binding activity; protein kinase binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of myotube differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MAML1-RBP-Jkappa- ICN1 complex.
RGD Description
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15692
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
179.735M179.740M179.745M179.750M179.755M179.760M179.765M179.770M179.775M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions