Gene

COLEC12

Species
Homo sapiens
Symbol
COLEC12
Name
collectin subfamily member 12
Synonyms
  • CLP1
  • collectin placenta 1
Biotype
protein coding gene
Automated Description
Enables low-density lipoprotein particle binding activity; pattern recognition receptor activity; and scavenger receptor activity. Involved in several processes, including cellular response to exogenous dsRNA; phagocytosis, recognition; and toll-like receptor 3 signaling pathway. Acts upstream of with a positive effect on plasma membrane raft organization. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space.
RGD Description
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22803
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            COLEC12 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              COLEC12 role
              COLEC12 genetic perturbation
              Interactor gene
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