Gene

CKS1B

Species
Homo sapiens
Symbol
CKS1B
Name
CDC28 protein kinase regulatory subunit 1B
Synonyms
  • CDC2-associated protein CKS1
  • CDC28 protein kinase 1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to act upstream of or within fibroblast proliferation; mitotic cell cycle phase transition; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex.
RGD Description
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23415
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
154.9750M154.9755M154.9760M154.9765M154.9770M154.9775M154.9780M154.9785M154.9790M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions