Gene

ABHD8

Species
Homo sapiens
Symbol
ABHD8
Name
abhydrolase domain containing 8
Synonyms
  • abhydrolase domain-containing protein 8
  • alpha/beta hydrolase domain-containing protein 8
Biotype
protein coding gene
Automated Description
Predicted to enable hydrolase activity. Located in extracellular exosome.
RGD Description
This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42886
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusAbhd810 of 10YesYes  
Rattus norvegicusAbhd810 of 10YesYes  
Xenopus laevisabhd8.L1 of 1YesYes           
Xenopus laevisabhd8.S1 of 1YesYes           
Xenopus tropicalisabhd88 of 9YesYes   
Danio rerioabhd8b9 of 10YesYes  
Danio rerioabhd8a4 of 10NoYes  
Saccharomyces cerevisiaeEAT12 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
EPHX3136735222 of 8  
EPHX4233237252 of 8  
ABHD4328336233 of 8  
SERHL2432733202 of 8  
EPHX2528535222 of 8  
BPHL627637222 of 8  
MEST728732212 of 8  
ABHD11825738202 of 8  
ABHD6928732182 of 8  
ABHD51011146283 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
17.294M17.296M17.298M17.300M17.302M17.304M17.306M17.308M17.310M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000019.10:g.17300911C>Tvariant
SNP
  • missense variant
NC_000019.10:g.17301216C>Tvariant
SNP
  • missense variant
NC_000019.10:g.17300973G>Avariant
SNP
  • missense variant
NC_000019.10:g.17294827G>Cvariant
SNP
  • missense variant
NC_000019.10:g.17306171T>Cvariant
SNP
  • missense variant
NC_000019.10:g.17306302C>Gvariant
SNP
  • missense variant
NC_000019.10:g.17306209G>Avariant
SNP
  • missense variant
NC_000019.10:g.17306261A>Gvariant
SNP
  • missense variant
NC_000019.10:g.17292719T>Gvariant
SNP
  • missense variant
NC_000019.10:g.17301211C>Tvariant
SNP
  • missense variant
Showing 1 - 10 of 33 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

12 interactor genes based on 15 annotations
ABHD8 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
BRD3Homo sapiens
protein
  • affinity chromatography technology
PMID:31753913
protein
CHMP4CHomo sapiens
protein
  • affinity chromatography technology
PMID:31586073
protein
FNDC3BHomo sapiens
protein
  • two hybrid
PMID:32296183
protein
LMO2Homo sapiens
protein
  • affinity chromatography technology
PMID:28514442
protein
LMO2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
NSARS-CoV-2
protein
  • affinity chromatography technology
PMID:39225180
protein
NLRP3Homo sapiens
protein
  • fluorescent resonance energy transfer
PMID:39225180
protein
NLRP3Homo sapiens
protein
  • affinity chromatography technology
PMID:39225180
protein
NLRP3Homo sapiens
protein
  • affinity chromatography technology
PMID:39225180
protein
OR52N5Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
Showing 1 - 10 of 14 rows
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Genetic Interactions

ABHD8 role
ABHD8 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
EGFRHomo sapiens
unspecified role
positive genetic interaction (sensu BioGRID)
  • Growth abnormality
  • viability
PMID:31741433
Showing 1 - 1 of 1 rows
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