Gene

LRTM1

Species
Homo sapiens
Symbol
LRTM1
Name
leucine rich repeats and transmembrane domains 1
Synonyms
  • HT017
  • leucine-rich repeat and transmembrane domain-containing protein 1
Biotype
protein coding gene
Automated Description
Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane.
RGD Description
Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24369
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusLrtm110 of 10YesYes  
Rattus norvegicusLrtm11 of 10YesYes  
Xenopus laevislrtm1.S1 of 1YesYes           
Xenopus laevislrtm1.L1 of 1YesYes           
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
LRTM2135454373 of 8  
LRRC4C247334212 of 8  
LRRTM4350631202 of 8  
SLIT3435945272 of 8  
RTN4RL2541536242 of 8  
ISLR2635141272 of 8  
LRRC24730546322 of 8  
FLRT3839737222 of 8  
RTN4RL1939934242 of 8  
LRRC41039735232 of 8  
LRRC4B1135035233 of 8  
SLIT11227047322 of 8  
LRFN41333937242 of 8  
CHAD1435236242 of 8  
LRRC151528245282 of 8  
RTN4R1630939272 of 8  
ISLR1726945302 of 8  
SLIT21823550322 of 8  
LRFN31932135252 of 8  
LRIT1202 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
LRTM1 (Hsa)
Lrtm1 (Mmu)
Lrtm1 (Rno)
lrtm1.L (Xla)
lrtm1.S (Xla)
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
54.920M54.925M54.930M54.935M54.940M54.945M54.950M54.955M54.960M54.965M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000003.12:g.54918661G>Avariant
SNP
  • missense variant
NC_000003.12:g.54918580G>Avariant
SNP
  • missense variant
NC_000003.12:g.54918625A>Gvariant
SNP
  • missense variant
NC_000003.12:g.54924844G>Avariant
SNP
  • missense variant
NC_000003.12:g.54918638C>Avariant
SNP
  • missense variant
NC_000003.12:g.54918709G>Avariant
SNP
  • missense variant
NC_000003.12:g.54918872T>Cvariant
SNP
  • missense variant
NC_000003.12:g.54924640G>Cvariant
SNP
  • missense variant
NC_000003.12:g.54924736G>Avariant
SNP
  • stop gained
NC_000003.12:g.54924846T>Cvariant
SNP
  • missense variant
Showing 1 - 10 of 20 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Details

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Expression

Primary Sources
None
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 7 annotations
LRTM1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ATPAF2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
GNPDA2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
MALHomo sapiens
protein
  • two hybrid
PMID:32296183
protein
NAE1Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
PITHD1Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
PTPRFHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
UBA3Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
Showing 1 - 7 of 7 rows
per page

Genetic Interactions

No data available