Gene

FYN

Species
Homo sapiens
Symbol
FYN
Name
FYN proto-oncogene, Src family tyrosine kinase
Synonyms
  • c-syn protooncogene
  • FYN oncogene related to SRC, FGR, YES
Biotype
protein coding gene
Automated Description
Enables several functions, including disordered domain specific binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to amyloid-beta; and peptidyl-tyrosine phosphorylation. Located in cytosol; endosome; and plasma membrane. Is active in dendrite and membrane raft. Implicated in Alzheimer's disease; alcohol dependence; and schizophrenia. Biomarker of Alzheimer's disease.
RGD Description
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46037
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            111.68M111.70M111.72M111.74M111.76M111.78M111.80M111.82M111.84M111.86M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            FYN molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              FYN role
              FYN genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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