Gene

GSTP1

Species
Homo sapiens
Symbol
GSTP1
Name
glutathione S-transferase pi 1
Synonyms
  • deafness, X-linked 7
  • DFN7
Biotype
protein coding gene
Automated Description
Enables several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Involved in several processes, including fatty acid metabolic process; negative regulation of macromolecule metabolic process; and negative regulation of signal transduction. Located in cytosol and mitochondrion. Part of TRAF2-GSTP1 complex. Implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Biomarker of several diseases, including acute kidney failure; carcinoma (multiple); conjunctivochalasis; lung disease (multiple); and multiple myeloma.
RGD Description
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11571
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
GSTA3120052335 of 8  
GSTA2220450305 of 8  
GSTA1320649285 of 8  
GSTM3421252324 of 8  
GSTA4519549315 of 8  
GSTA5619351305 of 8  
GSTM2721151314 of 8  
GSTM5820750304 of 8  
GSTM1921149284 of 8  
GSTM41018852304 of 8  
HPGDS1122043243 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Elevated diastolic blood pressure
Osteoporosis
Preeclampsia
Proteinuria
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
67.5840M67.5845M67.5850M67.5855M67.5860M67.5865M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000011.10:g.67583826G>Avariant
SNP
  • 5 prime UTR variant
NC_000011.10:g.67586428A>Cvariant
SNP
  • missense variant
NC_000011.10:g.67586373C>Tvariant
SNP
  • intron variant
NC_000011.10:g.67584069A>Gvariant
SNP
  • intron variant
NC_000011.10:g.67584114C>Gvariant
SNP
  • intron variant
NC_000011.10:g.67584303C>Tvariant
SNP
  • intron variant
NC_000011.10:g.67584060G>Avariant
SNP
  • intron variant
NC_000011.10:g.67586398G>Avariant
SNP
  • missense variant
NC_000011.10:g.67586108C>Tvariant
SNP
  • intron variant
NC_000011.10:g.67585218A>Gvariant
SNP
  • missense variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(Rho-GSTP1)#Psbe
Drosophila melanogasterHsap\GSTP1A114V.UAS
  • UASt
Drosophila melanogasterHsap\GSTP1I105V.UAS
  • UASt
Drosophila melanogasterHsap\GSTP1WT.UAS
  • UASt
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
67.5840M67.5845M67.5850M67.5855M67.5860M67.5865M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

207 interactor genes based on 240 annotations
GSTP1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ABHD14BHomo sapiens
protein
  • biochemical
PMID:35831314
protein
ACO2Homo sapiens
protein
  • biochemical
PMID:31536960
protein
ACTA2Homo sapiens
protein
  • biochemical
PMID:22939629
protein
ACY1Homo sapiens
protein
  • affinity chromatography technology
PMID:26496610
protein
ADAMTSL4Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
AGR2Homo sapiens
protein
  • affinity chromatography technology
PMID:31436131
protein
AIMP2Homo sapiens
protein
  • affinity chromatography technology
PMID:35546148
protein
ALDH4A1Homo sapiens
protein
  • biochemical
PMID:31536960
protein
ANLNHomo sapiens
protein
  • affinity chromatography technology
PMID:36526897
protein
ANXA5Homo sapiens
protein
  • biochemical
PMID:31536960
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Genetic Interactions

No data available