Predicted to enable lipid binding activity; phosphatidylinositol trisphosphate phosphatase activity; and phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; and signal transduction. Predicted to act upstream of or within several processes, including negative regulation of osteoclast differentiation; phosphatidylinositol dephosphorylation; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm.
RGD Description
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]