Gene

INPP4B

Species
Homo sapiens
Symbol
INPP4B
Name
inositol polyphosphate-4-phosphatase type II B
Synonyms
  • 4-phosphatase II
  • inositol polyphosphate 4-phosphatase II
Biotype
protein coding gene
Automated Description
Predicted to enable lipid binding activity; phosphatidylinositol trisphosphate phosphatase activity; and phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; and signal transduction. Predicted to act upstream of or within several processes, including negative regulation of osteoclast differentiation; phosphatidylinositol dephosphorylation; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm.
RGD Description
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12187
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
142.1M142.2M142.3M142.4M142.5M142.6M142.7M142.8M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions