Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
---|---|---|---|---|---|
Mus musculus | Nf2 | 9 of 10 | Yes | Yes | ☐☑☑☑☑☑☑☑☑☑ |
Rattus norvegicus | Nf2 | 9 of 10 | Yes | Yes | ☐☑☑☑☑☑☑☑☑☑ |
Xenopus laevis | nf2.S | 1 of 1 | Yes | Yes | ☑ |
Xenopus laevis | nf2.L | 1 of 1 | Yes | Yes | ☑ |
Xenopus tropicalis | nf2 | 5 of 9 | Yes | Yes | ☑ ☐☐☑☑☐☑☑☐ |
Danio rerio | nf2a | 9 of 10 | Yes | Yes | ☐ ☑☑☑☑☑☑☑☑ ☑ |
Danio rerio | nf2b | 1 of 10 | No | Yes | ☐ ☐☐☐☐☐☐☐☐ ☑ |
Drosophila melanogaster | Mer | 8 of 9 | Yes | Yes | ☐ ☑☑☑☑☑☑☑☑ |
Caenorhabditis elegans | nfm-1 | 3 of 9 | Yes | Yes | ☐ ☐☐☐☑☐☑☑☐ |
Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
---|---|---|---|---|---|---|
MSN | 1 | 603 | 65 | 47 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
EZR | 2 | 605 | 65 | 46 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
RDX | 3 | 616 | 63 | 46 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
FRMD4B | 4 | 678 | 41 | 22 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
FRMD4A | 5 | 593 | 43 | 25 | 2 of 8 | ☑ ☐☐☐☐☐☑☐ |
Phenotype Term | Annotation details | References |
---|---|---|
Abnormal brain FDG positron emission tomography | ||
Abnormal central motor function | ||
Abnormal central sensory function | ||
Abnormal cerebellum morphology | ||
Abnormal hypothalamus physiology | ||
Abnormal kinetic perimetry test | ||
Abnormal mediastinum morphology | ||
Abnormal optic nerve morphology | ||
Abnormal speech pattern | ||
Abnormality of the eye |
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
---|---|---|---|---|---|---|---|---|
Homo sapiens | NF2 | is marker for | acoustic neuroma |
| ||||
Homo sapiens | NF2 | is implicated in | colorectal cancer |
| ||||
Homo sapiens | NF2 | is implicated in | familial meningioma |
| ||||
Homo sapiens | NF2 | is implicated in | gastrointestinal stromal tumor |
| ||||
Homo sapiens | NF2 | is marker for | hepatocellular carcinoma |
| ||||
Homo sapiens | NF2 | is marker for |
| hepatocellular carcinoma |
| |||
Homo sapiens | NF2 | is implicated in | hepatocellular carcinoma |
| ||||
Homo sapiens | NF2 | is marker for | lung non-small cell carcinoma |
| ||||
Homo sapiens | NF2 | is implicated in |
| malignant pleural mesothelioma |
| |||
Homo sapiens | NF2 | is implicated in | malignant pleural mesothelioma |
|
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
---|---|---|---|---|---|---|---|
NC_000022.11:g.29604002G>T | variant | SNP
| |||||
NC_000022.11:g.29695006C>T | variant | SNP
| |||||
NC_000022.11:g.29604110G>T | variant | SNP
| |||||
NC_000022.11:g.29604070G>C | variant | SNP
| |||||
NC_000022.11:g.29604071A>G | variant | SNP
| |||||
NC_000022.11:g.29636780T>C | variant | SNP
| |||||
NC_000022.11:g.29636786G>A | variant | SNP
| |||||
NC_000022.11:g.29604053C>T | variant | SNP
| |||||
NC_000022.11:g.29636871A>G | variant | SNP
| |||||
NC_000022.11:g.29639143C>G | variant | SNP
|
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
---|---|---|---|---|---|---|---|
Mus musculus | Tg(NF2dCt)1Gth | ||||||
Drosophila melanogaster | Hsap\NF21-301.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF21-356.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2300-595.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2351-595.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2K413E.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2L64P.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2R466X.UAS.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2UAS.Iso1.Tag:FLAG |
|
| ||||
Drosophila melanogaster | Hsap\NF2UAS.Iso2.Tag:FLAG |
|
|
all annotations | all anatomical structures | alimentary part of gastrointestinal system | chemosensory system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | mechanosensory system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | sensory system | vestibulo-auditory system | visual system | endoderm | ectoderm | mesoderm | mesenchyme | adipose tissue | appendage | entire extraembryonic component | imaginal precursor | pharyngeal arch | other | all stages | embryo stage | post embryonic, pre-adult | post-juvenile adult stage | all cellular components | extracellular region | plasma membrane | synapse | cell junction | cell projection | cytoplasmic vesicle | endosome | vacuole | golgi apparatus | endoplasmic reticulum | cytosol | mitochondrion | nucleus | chromosome | cytoskeleton | protein-containing complex | other locations | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NF2 role | NF2 genetic perturbation | Interactor gene | Interactor species | Interactor role | Interactor genetic perturbation | Interaction type | Phenotype or trait | Source | Reference |
---|---|---|---|---|---|---|---|---|---|
unspecified role | ACOT9 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | AGO4 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | AK2 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | ALS2CL | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | ARID2 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | ASB6 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | BRIP1 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | BZW1 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | DDX19A | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 | |||
unspecified role | DYRK2 | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:35559673 |