Gene

CCN3

Species
Homo sapiens
Symbol
CCN3
Name
cellular communication network factor 3
Synonyms
  • CCN family member 3
  • IBP-9
Biotype
protein coding gene
Automated Description
Enables Notch binding activity and integrin binding activity. Involved in several processes, including endothelial cell-cell adhesion; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in cytoplasm; gap junction; and intracellular membrane-bounded organelle. Biomarker of pre-eclampsia and stomach cancer.
RGD Description
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11348
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
119.417M119.418M119.419M119.420M119.421M119.422M119.423M119.424M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions