Enables Notch binding activity and integrin binding activity. Involved in several processes, including endothelial cell-cell adhesion; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in cytoplasm; gap junction; and intracellular membrane-bounded organelle. Biomarker of pre-eclampsia and stomach cancer.
RGD Description
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]