Gene

NUP85

Species
Homo sapiens
Symbol
NUP85
Name
nucleoporin 85
Synonyms
  • 85 kDa nucleoporin
  • FLJ12549
Biotype
protein coding gene
Automated Description
Predicted to be a structural constituent of nuclear pore. Involved in nephron development. Located in cytosol; kinetochore; and nucleoplasm. Part of nuclear pore outer ring. Implicated in nephrotic syndrome type 17.
RGD Description
This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13373
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
75.210M75.215M75.220M75.225M75.230M75.235M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions