Gene

PTP4A2

Species
Homo sapiens
Symbol
PTP4A2
Name
protein tyrosine phosphatase 4A2
Synonyms
  • HH13
  • HH7-2
Biotype
protein coding gene
Automated Description
Predicted to enable enzyme inhibitor activity and protein tyrosine phosphatase activity. Predicted to be involved in chromatin remodeling. Located in cytoplasm.
RGD Description
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23339
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            31.910M31.915M31.920M31.925M31.930M31.935M31.940M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            PTP4A2 molecule type
            Interactor gene
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              Genetic Interactions

              PTP4A2 role
              PTP4A2 genetic perturbation
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