Enables calcium sensitive guanylate cyclase activator activity. Acts upstream of or within phototransduction; regulation of guanylate cyclase activity; and visual perception. Located in photoreceptor outer segment. Is expressed in retina outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 48. Orthologous to human GUCA1B (guanylate cyclase activator 1B).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal rod electrophysiology. [provided by MGI curators]