Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; heart; and metanephros. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos before E11.5. vascular remodeling does not take place normally. [provided by MGI curators]