Enables fatty acid binding activity; lysophosphatidic acid acyltransferase activity; and phosphatidylinositol 3-kinase activator activity. Involved in several processes, including autophagic cell death; positive regulation of autophagosome assembly; and regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Acts upstream of or within 'de novo' post-translational protein folding; phosphatidic acid biosynthetic process; and positive regulation of establishment of protein localization to mitochondrion. Located in membrane. Part of protein-containing complex. Is expressed in several structures, including cerebellum; cerebral cortex; otocyst; and spleen. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in delayed apoptosis of embryonic fibroblasts in response to serum withdrawal or treatment with a mitochondrial stress inducer. [provided by MGI curators]