Gene

Dync2li1

Species
Mus musculus
Symbol
Dync2li1
Name
dynein cytoplasmic 2 light intermediate chain 1
Synonyms
  • 4933404O11Rik
  • CGI-60
Biotype
protein coding gene
Automated Description
Predicted to enable dynein heavy chain binding activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Located in apical part of cell; axoneme; and motile cilium. Is expressed in several structures, including gut; heart; lung; metanephros; and node. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this allele die before embryonic day 11.5. They display neural tube defects in addition to a variety developmental patterning abnormalities. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13236
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Dync2li1tm1Aar/Dync2li1tm1Aar [background:] involves: 129P2/OlaHsd
  • abnormal anterior definitive endoderm morphology
  • abnormal developmental patterning
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
84.935M84.940M84.945M84.950M84.955M84.960M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available