Enables identical protein binding activity and signaling receptor binding activity. Involved in regulation of lipid metabolic process. Acts upstream of or within positive regulation of D-glucose import; positive regulation of MAPK cascade; and positive regulation of small molecule metabolic process. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skeleton. Orthologous to human C1QTNF2 (C1q and TNF related 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele show decreased body weight, reduced adiposity, increased metabolic rate and energy expenditure, enhanced adipose tissue lipolysis, and altered hepatic and plasma lipid profiles.
[provided by MGI curators]