Gene

Mff

Species
Mus musculus
Symbol
Mff
Name
mitochondrial fission factor
Synonyms
  • 5230400G24Rik
  • AI314724
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase binding activity and protein homodimerization activity. Involved in mitochondrial fission and protein targeting to mitochondrion. Located in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 2. Orthologous to human MFF (mitochondrial fission factor).
MGI Description
PHENOTYPE: Homozygous knockout reduces mitochondrial hyperfusion-induced apoptotic cell death of cardiac microcirculation endothelial cells after ischemia/reperfusion injury. Males exhibit sperm mitochondrial abnormalities associated with reduced respiratory chain complex IV activity, motility, and fertility. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16501
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
82.705M82.710M82.715M82.720M82.725M82.730M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions