Predicted to enable GTPase binding activity and protein homodimerization activity. Involved in mitochondrial fission and protein targeting to mitochondrion. Located in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 2. Orthologous to human MFF (mitochondrial fission factor).
MGI Description
PHENOTYPE: Homozygous knockout reduces mitochondrial hyperfusion-induced apoptotic cell death of cardiac microcirculation endothelial cells after ischemia/reperfusion injury. Males exhibit sperm mitochondrial abnormalities associated with reduced respiratory chain complex IV activity, motility, and fertility. [provided by MGI curators]