Predicted to enable ribosome binding activity; translation initiation factor binding activity; and translation repressor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell activation. Acts upstream of or within cell population proliferation and gene expression. Is active in nucleus. Is expressed in 1-cell stage embryo; cap mesenchyme; eye; integumental system; and tongue epithelium. Orthologous to human DAPL1 (death associated protein like 1).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit increased proliferation of retinal pigment epithelial cells forming multiple layers. [provided by MGI curators]