Gene

Mtch2

Species
Mus musculus
Symbol
Mtch2
Name
mitochondrial carrier 2
Synonyms
  • 2310034D24Rik
  • 4930539J07Rik
Biotype
protein coding gene
Automated Description
Predicted to enable membrane insertase activity. Involved in several processes, including lipid homeostasis; positive regulation of stem cell differentiation; and regulation of mitochondrial fusion. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; hepatocyte apoptotic process; and mitochondrial membrane organization. Located in mitochondrial outer membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; integumental system; and liver and biliary system. Orthologous to human MTCH2 (mitochondrial carrier 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal mesoderm development, disorganized extraembryonic tissue, lack of amnion and chorion formation, decreased embryo size, and lethality at around E7.5. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10780
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            90.678M90.680M90.682M90.684M90.686M90.688M90.690M90.692M90.694M90.696M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Mtch2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Mtch2 role
              Mtch2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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