Enables ubiquitin protein ligase activity. Involved in dendritic transport. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Located in vesicle. Is expressed in genitourinary system; hippocampus; and retina nuclear layer. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1).
MGI Description
PHENOTYPE: Nullizygous mutations can cause neonatal or postnatal lethality associated with severe skin inflammation, high mast cell numbers and serum levels of IgE and histamine, and enhanced mast cell degranulation and release of mediators and cytokines in response to high affinity IgE receptor aggregation. [provided by MGI curators]