Predicted to enable protein-macromolecule adaptor activity and zf-TRAF domain binding activity. Acts upstream of or within several processes, including antiviral innate immune response; cellular response to cytokine stimulus; and positive regulation of type I interferon production. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including cerebral cortex; eye; foregut; limb segment; and vertebral axis musculature. Orthologous to human TRAF3IP3 (TRAF3 interacting protein 3).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired single positive thymocyte development and increased gamma-delta T cell numbers.
[provided by MGI curators]