Gene

Kalrn

Species
Mus musculus
Symbol
Kalrn
Name
kalirin, RhoGEF kinase
Synonyms
  • 2210407G14Rik
  • AV235988
Biotype
protein coding gene
Automated Description
Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including learning or memory; maternal behavior; and maternal process involved in parturition. Predicted to be located in several cellular components, including neuronal cell body; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density; and presynapse. Predicted to be extrinsic component of membrane. Is expressed in cerebral cortex ventricular layer; cortical plate; dorsal root ganglion; and spinal cord. Human ortholog(s) of this gene implicated in cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22826
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
33.8M33.9M34.0M34.1M34.2M34.3M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions