Gene

Cdk4

Species
Mus musculus
Symbol
Cdk4
Name
cyclin dependent kinase 4
Synonyms
  • CDC2-related kinase 3
  • Crk3
Biotype
protein coding gene
Automated Description
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to ionomycin; cellular response to lipopolysaccharide; and cellular response to phorbol 13-acetate 12-myristate. Located in bicellular tight junction and nucleus. Part of cyclin D1-CDK4 complex; cyclin D2-CDK4 complex; and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; nervous system; sensory organ; and urinary system. Used to study skin melanoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4).
MGI Description
PHENOTYPE: Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24056
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
126.8995M126.9000M126.9005M126.9010M126.9015M126.9020M126.9025M126.9030M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions