Gene

Irf8

Species
Mus musculus
Symbol
Irf8
Name
interferon regulatory factor 8
Synonyms
  • AI893568
  • expressed sequence AI893568
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mononuclear cell differentiation; regulation of transcription by RNA polymerase II; and regulation of type I interferon production. Acts upstream of or within several processes, including defense response to protozoan; positive regulation of macromolecule biosynthetic process; and response to bacterium. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and lens. Used to study familial chronic myelocytic leukemia-like syndrome. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8).
MGI Description
PHENOTYPE: Homozygotes for a targeted null mutation exhibit increased incidence of viral infections, shortened life span, deregulated hematopoiesis, and hematological neoplasias. Heterozygotes show similar, but milder, phenotypes. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11949
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
121.464M121.466M121.468M121.470M121.472M121.474M121.476M121.478M121.480M121.482M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions