Gene

Sppl3

Species
Rattus norvegicus
Symbol
Sppl3
Name
signal peptide peptidase like 3
Synonyms
  • LOC360822
  • RGD1562826
Biotype
protein coding gene
Automated Description
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and proteolysis. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane; plasma membrane; and rough endoplasmic reticulum. Predicted to be active in Golgi-associated vesicle membrane; cytoplasmic side of endoplasmic reticulum membrane; and lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL3 (signal peptide peptidase like 3).
RGD Description
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and signal peptide processing. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane; plasma membrane; and rough endoplasmic reticulum. Predicted to be active in Golgi-associated vesicle membrane; cytoplasmic side of endoplasmic reticulum membrane; and lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL3 (signal peptide peptidase like 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12174
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
41.52M41.53M41.54M41.55M41.56M41.57M41.58M41.59M41.60M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions